Human leukocyte antigen DR15, a possible predictive marker for immune checkpoint inhibitor-induced secondary adrenal insufficiency.

Yano S, Ashida K, Ryuichi Sakamoto R, Sakaguchi C, Ogata M, Maruyama K, Sakamoto S, Ikeda M, Ohe K, Akasu S, Iwata S, Wada N, Matsuda Y, Nakanishi Y, Nomura M, Ogawa Y.
Eur J Cancer. 2020; 130: 198-203.

Necessity of utilizing physiological glucocorticoids for managing familial Mediterranean fever.

Ashida K, Terada E, Nagayama A, Sakamoto S, Hasuzawa N, Nomura M.
Am J Case Rep 2020;21:e920983.

High prevalence of diabetes in patients with primary aldosteronism (PA) associated with subclinical hypercortisolism and prediabetes more prevalent in bilateral than unilateral PA: A large multicenter cohort study in Japan.

Akehi Y, Yanase T, Motonaga R, Umakoshi H, Tsuiki M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki O, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M.
Diabetes care 2019;42:938-945.

Human Leukocyte Antigen (HLA) Subtype-Dependent Development of Myasthenia Gravis, Type-1 Diabetes Mellitus, and Hashimoto Disease: A Case Report of Autoimmune Polyendocrine Syndrome Type 3.

Gobaru M, Ashida K, Yoshinobu S, Nagayama A, Kabashima M, Iwata S, Hasuzawa N, Tsuruta M, Wada N, Nakayama H, Motomura S, Tajiri Y, Nomura M.
Am J Case Rep. 2019 Nov 20;20:1709-1714.

Metreleptin Supplementation for Improving Lipid and Glycemic Profiles in Acquired Diabetes Lipodystrophy: A Case Report.

Nagayama A, Ashida K, Moritaka K, Hidaka M, Gobaru M, Tanaka S, Hasuzawa N, Akasu S, Goto Y, Motomura S, Hara K, Tsuruta M, Wada N, Nakayama H, Tajiri Y, Nomura M.
J Endocr Soc. 2019 Sep 16;3(11):2179-2183

Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study.

Takekoshi K, Satoh F, Tanabe A, Okamoto T, Ichihara A, Tsuiki M, Katabami T, Nomura M, Tanaka T, Matsuda T, Imai T, Yamada M, Asada S, Kawata N, Naruse M
Endocr J. 2019 Dec 25;66(12):1063-1072.

Bromocriptine as a Potential Glucose-lowering Agent for the Treatment of Prolactinoma with Type 2 Diabetes.

Oshige T, Nakamura Y, Sasaki Y, Kawano S, Ohki T, Tsuruta M, Tokubuchi I, Nakayama H, Yamada K, Ashida K, Tajiri Y, Nomura M.
Intern Med. 2019 Jun 27. 2755-19.

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of 18F-fluorodeoxyglucose in sporadic paraganglioma: A case report.

Terada E, Ashida K, Ohe K, Sakamoto S, Hasuzawa N, Nomura M.
Clin Case Rep. 2019 Jun 11;7(7):1399-1403.

Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line.

Uchida K, Nomura M, Yamamoto T, Ogawa Y, Teramoto N.
Pflugers Arch. 2019 Jun;471(6):877-887.

High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan.

Akehi Y, Yanase T, Motonaga R, Umakoshi H, Tsuiki M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki O, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M.
Diabetes care 42(5):938-945, 2019.

A High-Fat/High-Sucrose Diet Induces WNT4 Expression in Mouse Pancreatic β-cells.

Kurita Y, Ohki T, Soejima E, Yuan X, Kakino S, Wada N, Hashinaga T, Nakayama H, Tani J, Tajiri Y, Hiromatsu Y, Yamada K, Nomura M.
Kurume Med J. 2019 May 16;65(2):55-62.

A case of nivolumab-induced acute-onset type 1 diabetes mellitus in melanoma.

Sakaguchi C, Ashida K, Yano S, Ohe K, Wada N, Hasuzawa N, Matsuda Y, Sakamoto S, Sakamoto R, Uchi H, Furue M, Nomura M, Ogawa Y.
Curr Oncol. 26: e115-e118, 2019.

Acute exacerbation of chronic adrenal insufficiency caused by ipilimumab: a case report of melanoma.

Sakaguchi C, Yano S, Ashida K, Wada N, Ohe K, Nagata H, Sakamoto S, Sakamoto R, Ohnaka K, Uchi H, Furue M, Nomura M, Ogawa Y.
Am J Case Rep. 20:106-110, 2019.

A case of autonomous cortisol secretion in a patient with subclinical Cushing’s syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

Sakaguchi C, Ashida K, Kohashi K, Ohe K, Fujii Y, Yano S, Matsuda Y, Sakamoto S, Sakamoto R, Oda Y, Nomura M, Ogawa Y.
BMC Endocr Disord. 2019 Jan 22;19(1):13.

PDCD4 knockdown induces senescence in hepatoma cells by up-regulating the p21 expression.

Guo J, Ozaki I, Xia J, Kuwashiro T, Kojima M, Takahashi H, Ashida K, Anzai K, Matsuhashi S.
Front Oncol. 2019 Jan 9;8:661.

Protective effect of 3-hydroxybutyrate against endoplasmic reticulum stress-associated vascular endothelial cell damage induced by low glucose exposure.

Soejima E, Ohki T, Kurita Y, Yuan X, Tanaka K, Kakino S, Hara K, Nakayama H, Tajiri Y, Yamada K.
PLOS ONE 13(3)：e0191147，2018.

Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.

Sasaki H, Yanagi K, Ugi S, Kobayashi K, Ohkubo K, Tajiri Y, Maegawa H, Kashiwagi A, Kaname T.
Endocr J. 2018 Feb 26;65(2):227-238.

Clinical Factors Associated with Initial Decrease in Body-Fat Percentage Induced by Add-on Sodium-Glucose Co-transporter 2 Inhibitors in Patient with Type 2 Diabetes Mellitus.

Kurinami N, Sugiyama S, Nishimura H, Morita A, Yoshida A, Hieshima K, Miyamoto F, Kajiwara K, Jinnouchi K, Jinnouchi T, Jinnouchi H.
Clinical Drug Investigation 38(1)：19-27，2018.

Autoimmune-related primary hypoparathyroidism possibly induced by the administration of pembrolizumab: A case report.

Umeguchi H, Takenoshita H, Inoue H, Kurihara Y, Sakaguchi C, Yano S, Hasuzawa N, Sakamoto S, Sakamoto R, Ashida K.
J Oncol Pract. 14(7):449-451, 2018.

Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma.

Yano S, Ashida K, Nagata H, Ohe K, Wada N, Takeichi Y, Hanada Y, Ibayashi Y, Wang L, Sakamoto S, Sakamoto R, Uchi H, Shiratsuchi M, Furue M, Nomura M, Ogawa Y.
BMC Endocr Disord. 2018 Jun 8;18(1):36.

HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.

Ohe K, Miyajima S, Abe I, Tanaka T, Hamaguchi Y, Harada Y, Horita Y, Beppu Y, Ito F, Yamasaki T, Terai H, Mori M, Murata Y, Tanabe M, Ashida K, Kobayashi K, Enjoji M, Yanase T, Harada N, Utsumi T, Mayeda A.
J Steroid Biochem Mol Biol. 182:21-26, 2018.

Correlation between Lateralization Index 1 of Adrenal Venous Sampling and Standardized Outcome in Primary Aldosteronism.

Umakoshi H, Tsuiki M, Yokomoto-Umakoshi M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Yanase T, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M.
J Endocr Soc. 2: 893-902, 2018.

HMGA1a induces alternative splicing of the Estrogen Receptor-αlpha gene by trapping U1 snRNP to an upstream pseudo-5’ splice site.

Ohe K, Miyajima S, Tanaka T, Hamaguchi Y, Harada Y, Horita Y, Beppu Y, Ito F, Yamasaki T, Terai H, Mori M, Murata Y, Tanabe M, Abe I, Ashida K, Kobayashi K, Enjoji M, Nomiyama T, Yanase T, Harada N, Utsumi T, Mayeda A.
Front Mol Biosci. 5: 52, 2018.

Diurnal Variation of Sweet Taste Recognition Thresholds Is Absent in Overweight and Obese Humans.

Sanematsu K, Nakamura Y, Nomura M, Shigemura N, Ninomiya Y.
Nutrients. 2018 Mar 2;10(3). pii: E297. doi: 10.3390/nu10030297.

Clodronate: A Vesicular ATP Release Blocker.

Moriyama Y, Nomura M.
Trends Pharmacol Sci. 2018 Jan;39(1):13-23. doi: 10.1016/j.tips.2017.10.007.

Efficacy and safety of metyrosine in pheochromocytoma / paraganglioma: a multi-center trial in Japan.

Naruse M, Satoh F, Tanabe A, Okamoto T, Ichihara A, Tsuiki M, Katabami T,
Nomura M, Tanaka T, Matsuda T, Imai T, Yamada M, Harada T, Kawata N, Takekoshi K.
Endocr J. 2018 Jan 20. doi: 10.1507/endocrj.EJ17-0276.

Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model.

Kakino S, Ohki T, Nakayama H, Yuan X,
Otabe S, Hashinaga T, Wada N, Kurita Y, Tanaka K, Hara K, Soejima E, Tajiri Y, Yamada K.
Horm Metab Res. 2018 Jan;50(1):80-87. doi: 10.1055/s-0043-118666.

In Vivo Transgene Expression in the Pancreas by the Intraductal Injection of Naked Plasmid DNA.

Yamada Y, Tabata M, Abe J, Nomura M, Harashima H.
J Pharm Sci. 2018 Feb;107(2):647-653. doi: 10.1016/j.xphs.2017.09.021.

The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese.

Abe M, Ito H, Oze I, Nomura M, Ogawa Y, Matsuo K.
Journal of Cancer Research and Clinical Oncology 143(12)：2481-92，2017.

Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity.

Sugiyama K, Aida T, Nomura M, Takayanagi R, Zeilhofer HU, Tanaka K.
The Journal of Neuroscience 37(36)：8830-44，2017.

Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain.

Kato Y, Hiasa Y, Ichikawa R, Hasuzawa N, Kadowaki A, Iwatsuki K, Shima K, Endo Y, Kitahara Y, Inoue T, Nomura M, Omote H, Moriyama Y, Miyaji T.
Proc Natl Acad Sci U S A. 2017 Jul 18.

A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium.

Eritja N, Felip I, Dosil MA, Vigezzi L, Mirantes C, Yeramian A, Navaridas R, Santacana M, Llobet-Navas D, Yoshimura A, Nomura M, Encinas M, Matias-Guiu X, Dolcet X.
Cell Death and Differentiation 24(8)：1443-58，2017.

Three‐dimensional analysis of somatic mitochondrial dynamics in fission‐deficient injured motor neurons using FIB/SEM.

Tamada H, Kiryu-Seo S, Hosokawa H, Ohta K, Ishihara N, Nomura M, Mihara K, Nakamura K, Kiyama H.
The Journal of Comparative Neurology 525(11)：2535-48，2017.

Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates.

Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V.
Physiol Rep. 2017 Oct;5(19). e13447.

Different effect of in linagliptin and sitagliptin on blood pressure and renal function in Japanese patients with type 2 diabetes mellitus.

Tojikubo M, Tajiri Y.
Diabetology International 8(4)：397-401，2017.

Novel subtype of congenital partial lipodystrophy with mandibular hypoplasia, sensorineural deafness and short stature of unknown genetic origin.

Sasaki H, Ohkubo K, Kobayashi K, Tajiri Y, Ugi S, Kashwagi A.
J Diabetes Investig. 2017 Jan;8(1):121-122.

Isolated ACTH deficiency probably induced by autoimmune-related mechanism evoked with nivolumab.

Kitajima K, Ashida K, Wada N, Suetsugu R, Takeichi Y, Sakamoto S, Uchi H, Matsushima T, Shiratsuchi M, Ohnaka K, Furue M, Nomura M.
Japanese Journal of Clinical Oncology 47(5): 463-466, 2017.

Change of oral to topical corticosteroid therapy exacerbated glucose tolerance in a patient with plaque psoriasis.

Hongo Y, Ashida K, Ohe K, Enjoji M, Yamaguchi M, Kurata T, Emoto A, Yamanouchi H, Takagi S, Mori H, Kawata H, Hisata Y, Sakanishi Y, Izumi K, Sugioka T, Anzai K.
Am J Case Rep 18: 1198-1203, 2017.

Two cases of late-onset secondary adrenal insufficiency after discontinuation of nivolumab.

Otsubo K, Nakatomi K, Furukawa R, Ashida K, Yoneshima Y, Nakanishi Y, Okamoto I.
Ann Oncol 28(12): 3106-3107, 2017.

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.

Wang Y, Subramanian M, Yurdagul A Jr, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M, Maxfield FR, Tabas I.
Cell. 2017 Oct 5;171(2):331-345.e22. doi: 10.1016/j.cell.2017.08.041.

Vesicular nucleotide transporter (VNUT): appearance of an actress on the stage of purinergic signaling.

Moriyama Y, Hiasa M, Sakamoto S, Omote H, Nomura M.
Purinergic Signal. 2017 Sep;13(3):387-404. doi: 10.1007/s11302-017-9568-1.

SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.

Inoue C, Zhao C, Tsuduki Y, Udono M, Wang L, Nomura M, Katakura Y.
NPJ Aging Mech Dis. 2017 Aug 30;3:11. doi: 10.1038/s41514-017-0011-1.

Haemoglobin variants may cause significant differences in haemoglobin A1c as measured by high-performance liquid chromatography and enzymatic methods in diabetic patients: a cross-sectional study.

Otabe S, Nakayama H, Ohki T, Soejima E, Tajiri Y, Yamada K.
Ann Clin Biochem. 2017 Jul;54(4):432-437. doi: 10.1177/0004563216664366.

Beneficial effects of metformin on energy metabolism and visceral fat volume through a possible mechanism of fatty acid oxidation in human subjects and rats.

Tokubuchi I, Tajiri Y, Iwata S, Hara K, Wada N, Hashinaga T, Nakayama H, Mifune H, Yamada K.
PLoS One. 2017 Feb 3;12(2):e0171293. doi: 10.1371/journal.pone.0171293.

Effects of a sodium glucose co-transporter 2 selective inhibitor, ipragliflozin, on the diurnal profile of plasma glucose in patients with type 2 diabetes: A study using continuous glucose monitoring.

Yamada K, Nakayama H, Yoshinobu S, Kawano S, Tsuruta M, Nohara M, Hasuo R, Akasu S,
Tokubuchi I, Wada N, Hirao S, Iwata S, Kaku H, Tajiri Y.
J Diabetes Investig. 2015 Nov;6(6):699-707. doi: 10.1111/jdi.12370.

Cross-sectional and Longitudinal Analyses of Factors Contributing to the Progressive Loss of the β-cell Function in Type 2 Diabetes.

Nakayama H, Kato T, Nakayama S, Kaku H, Muraishi K, Tokubuchi I, Hara K, Kato T, Wada N,
Tsuruta M, Ohki T, Tanaka K, Mitsuzaki K, Tajiri Y, Yamada K.
Intern Med. 2015;54(16):1971-6. doi: 10.2169/internalmedicine.54.4351.

Liver Dysfunction Associated with Intravenous Methylprednisolone Pulse Therapy in Patients with Graves' Orbitopathy.

Eguchi H, Tani J, Hirao S, Tsuruta M, Tokubuchi I, Yamada K, Kasaoka M, Teshima Y, Kakuma T, Hiromatsu Y.
Int J Endocrinol. 2015;2015:835979. doi: 10.1155/2015/835979.

Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3).

Ohki T, Utsu Y, Morita S, Karim MF, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Kasayama S, Yamagata K.
J Diabetes Investig. 2014 Sep;5(5):513-6. doi: 10.1111/jdi.12237.

Age-related changes in the diurnal variation of ketogenesis in patients with type 2 diabetes and relevance to hypoglycemic medications.

Nakayama H, Tokubuchi I, Wada N, Tsuruta M, Ohki T, Oshige T, Sasaki Y, Iwata S, Kato N, Ohtsuka Y, Matsuo Y, Tajiri Y, Yamada K.
Endocr J. 2015;62(3):235-41. doi: 10.1507/endocrj.EJ14-0431.

Adding of Sitagliptin on Insulin Therapy Effectively and Safely Reduces a Hemoglobin A1c Level and Glucose Fluctuation in Japanese Patients with Type 2 Diabetes.

Tajiri Y, Kawano S, Hirao S, Oshige T, Iwata S, Ono Y, Inada C, Akashi T, Hayashi H, Sato Y, Tojikubo M, Yamada K.
Int Sch Res Notices. 2014 Aug 3;2014:639489. doi: 10.1155/2014/639489.

Selective modulation of Wnt ligands and their receptors in adipose tissue by chronic hyperadiponectinemia.

Wada N, Hashinaga T, Otabe S, Yuan X, Kurita Y, Kakino S, Ohoki T, Nakayama H, Fukutani T, Tajiri Y, Yamada K.
PLoS One. 2013 Jul 4;8(7):e67712. doi: 10.1371/journal.pone.0067712.

Prevalence and clinical characteristics of unremembered nocturnal eating in diabetic subjects: Kurume sleep trouble in obesity and metabolic disorders (KUSTOMED) study.

Yamada K, Nakayama H, Kato T, Tajiri Y, Sato S, Hirao S, Oshige T, Hara K, Iwata S, Kato N, Sasaki Y, Hasuo R, Yoshinobu S, Mitsuzaki K, Kato T, Hashinaga T, Muraishi K, Ohki T, Kaku H.
Endocr J. 2013;60(9):1059-63.

Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome.

Hashinaga T, Wada N, Otabe S, Yuan X, Kurita Y, Kakino S, Tanaka K, Sato T, Kojima M, Ohki T, Nakayama H, Egashira T, Tajiri Y, Yamada K.
Endocr J. 2013;60(4):483-92.

Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.

Ohki T, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Yamagata K.
Biochem Biophys Res Commun. 2012 Aug 31;425(3):619-24. doi: 10.1016/j.bbrc.2012.07.134.

Long-term efficacy of sitagliptin for the treatment of type 2 diabetic patients in Japan.

Tajiri Y, Tsuruta M, Ohki T, Kato T, Sasaki Y, Tanaka K, Kono S, Tojikubo M, Yamada K.
Endocr J. 2012;59(3):197-204.